Mobile Application should be secure, portable, cost-effective and be of good quality. The architecture choice is very important to ensure the quality of the application over time and to reduce development time. Model-View-Controller (MVC) is a very useful for developing Application. It has become the most powerful and leading Programming Architecture for developing a large scale of Application. MVC Developers can trust on the framework that is widely accepted as solutions for recurring problems and used to develop flexible, reusable and modular Application. In this study we investigate the advantage of using MVC Framework when building Mobile Application available on difference devices. In this study compares and contrasts two platforms, iOS and Android Devices, and discusses how to apply the MVC Framework in order to minimize the inherent differences between the platforms.